The 2001 South Carolina 2nd congressional district special election was held on December 18, 2001, to select a Representative for the 2nd congressional district to serve out the remainder of the term for the 107th Congress. The special election resulted from the death of 16-term Republican incumbent Floyd Spence on August 16, 2001. Joe Wilson, a state senator from Lexington County and a former aide to Spence, won the Republican primary and went on to win the general election against Democratic challenger Brent Weaver.
