The 2006 Eneco Tour road cycling race took place from 16 to 23 August, two weeks later in the season than the year before. The second edition of the Eneco Tour covered parts of the Netherlands, Belgium and Germany. As in 2005, 23 teams took part in the race. Next to the 20 UCI ProTour teams, Chocolade Jacques–Topsport Vlaanderen, Skil–Shimano and Unibet.com received wild card entries.
The race itself was very close, as both the prologue (6 km) and timetrial (16 km) were quite short which led to small time differences. A dramatic conclusion on the last day rendered Stefan Schumacher the victory over George Hincapie, with just one second of advantage. Other riders who stood out during this race were the Belgians Tom Boonen and Philippe Gilbert, who both won in their home region. Other wins came from Manuel Quinziato and David Kopp.