| Tournament details | |
|---|---|
| Country |  Northern Ireland Republic of Ireland |
| Teams | 8 |
| Defending champions | Linfield |
| Final positions | |
| Champions | Drogheda United (1st title) |
| Runner-up | Cork City |
| Tournament statistics | |
| Matches played | 27 |
| Goals scored | 59 (2.19 per match) |
The 2006 Setanta Sports Cup was the 2nd staging of the Setanta Sports Cup, a cross-border cup competition that takes place between football clubs from the Republic of Ireland and Northern Ireland. The final was played at Tolka Park in Dublin, Republic of Ireland on 22 April 2006, where Drogheda United beat Cork City to win the competition for the first time.