| Dates | 27 June 2006 – 12 August 2006 |
|---|---|
| Administrator(s) | England and Wales Cricket Board |
| Cricket format | Twenty20 |
| Tournament format(s) | Group stage and knockout |
| Champions | Leicestershire Foxes (2nd title) |
| Participants | 18 |
| Matches | 52 |
| Most runs | Justin Langer (464 for Somerset) |
| Most wickets | Nayan Doshi (21 for Surrey) |
The 2006 Twenty20 Cup was the fourth edition of what would later become the T20 Blast, England's premier domestic Twenty20 competition. The finals day took place on 12 August at Trent Bridge, Nottingham, and was won by the Leicestershire Foxes.