The forty-ninth edition of the Caribbean Series (Serie del Caribe) was played held from February 2 through February 7 of 2008, featuring the champion teams from Dominican Republic (Aguilas Cibaeñas), Mexico (Naranjeros de Hermosillo), Puerto Rico (Gigantes de Carolina) and Venezuela (Tigres de Aragua). The format consisted of 12 games, each team facing the other teams twice, and the games were played at Roberto Clemente Stadium in Carolina, Puerto Rico.