The 2008 United States House of Representatives elections in South Carolina were held on Tuesday, November 4, 2008. The primary elections were held on June 10 and the runoff elections were held two weeks later on June 24. The composition of the state delegation before the election was four Republicans and two Democrats.
All seats were considered safe for their incumbent parties except for districts 1 and 2. This was the last time that Democrats won more than one congressional district from South Carolina until 2018.