Wyoming was won by Republican nominee John McCain by a 32.2% margin of victory. Prior to the election, all 17 news organizations considered this a state McCain would win, or otherwise considered as a safe red state. Polling in the state gave a hefty and large lead to Republican John McCain over Democrat Barack Obama. Despite the overwhelming re-election victory of Democratic governor Dave Freudenthal two years prior, Wyoming remained a heavily Republican state at the presidential level, and neither of the major party candidates campaigned in the state.
Despite McCain's landslide victory, Obama did do significantly better than John Kerry in 2004 and even won one more county than Kerry. This is the most recent election in which the Democratic candidate received more than 30% of the vote in Wyoming, and the last in which the Republican nominee received fewer than double the votes of the Democratic nominee. Obama's 82,868 vote total remains the most received by a Democratic presidential candidate in the state's history. Obama became the first Democrat since Grover Cleveland in 1892 to win the White House without carrying Sweetwater County.