| 2010 Comerica Bank Challenger | |
|---|---|
| Date | July 12 – July 18 |
| Edition | 23rd |
| Location | Aptos, United States |
| Champions | |
| Singles | |
 Marinko Matosevic | |
| Doubles | |
| Carsten Ball / Chris Guccione | |
The 2010 Comerica Bank Challenger was a professional tennis tournament played on hard court. This was the twenty-third edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Aptos, United States between 12 July and 18 July 2010.