| Tournament details | |
|---|---|
| Country |  Cambodia |
| Teams | 34 |
| Final positions | |
| Champions | National Defense |
| Runner-up | Phnom Penh Crown |
| Tournament statistics | |
| Top goal scorer(s) | Kouch Sokumpheak, Srey Veasna (20 goals) |
The 2010 Hun Sen Cup was the 4th season of the Hun Sen Cup, the premier knockout tournament for association football clubs in Cambodia involving Cambodian League and provincial teams organized by the Football Federation of Cambodia.
Phnom Penh Crown were the defending champions, having beaten Nagacorp FC 1–0 in the previous season's final.