| 2010 St. Petersburg Open | |
|---|---|
| Date | 25–31 October |
| Edition | 16th |
| Category | ATP World Tour 250 Series |
| Draw | 32Q / 32S / 16D |
| Prize money | $663,750 |
| Surface | Hard / indoor |
| Location | St. Petersburg, Russia |
| Venue | Petersburg Sports and Concert Complex |
| Champions | |
| Singles | |
 Mikhail Kukushkin | |
| Doubles | |
 Daniele Bracciali / Potito Starace | |
The 2010 St. Petersburg Open was a tennis tournament played on indoor hard courts. It was the 16th edition of the St. Petersburg Open, and part of the ATP World Tour 250 Series of the 2010 ATP World Tour. It was held at the Petersburg Sports and Concert Complex in Saint Petersburg, Russia, from October 25 through October 31, 2010.