| Administrator(s) | England and Wales Cricket Board |
|---|---|
| Cricket format | 50 over |
| Tournament format(s) | League system |
| Champions | Sussex (5th title) |
| Participants | 37 |
| Most runs | Lydia Greenway (628) |
| Most wickets | Danni Wyatt (24) |
The 2010 Women's County One-Day Championship was the 14th cricket Women's County Championship season. It ran from May to September and saw 33 county teams and teams representing Ireland, Scotland, Wales and the Netherlands compete in a series of divisions. Sussex Women won the County Championship as winners of the top division, their fifth title.