| 2015 Knoxville Challenger | |
|---|---|
| Date | 8–15 November |
| Edition | 12th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Daniel Evans | |
| Doubles | |
 Johan Brunström /  Frederik Nielsen | |
The 2015 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Knoxville, United States between 8 and 15 November 2015.