| Tournament details | |
|---|---|
| Country |  Cambodia |
| Dates | 17 Feb - 02 Jul 2016 |
| Teams | 27 |
| Final positions | |
| Champions | National Defense Ministry |
| Runner-up | Preah Khan Reach |
| Tournament statistics | |
| Top goal scorer(s) | Suong Virak (25 goals) |
The Hun Sen Cup was the main football knockout tournament in Cambodia. The 2016 Hun Sen Cup was the 10th season of the Hun Sen Cup, the premier knockout tournament for association football clubs in Cambodia involving Cambodian League and provincial teams organized by the Football Federation of Cambodia.
Preah Khan Reach Svay Rieng were the defending champions, having beaten Nagaworld 2–1 in the previous season's final.