| 2018 Columbus Challenger | |
|---|---|
| Date | 17–23 September |
| Edition | 5th |
| Draw | 32S / 16D |
| Surface | Hard / Indoors |
| Location | Columbus, United States |
| Champions | |
| Singles | |
 Michael Mmoh | |
| Doubles | |
Tommy Paul /  Peter Polansky | |
The 2018 Columbus Challenger was a professional tennis tournament played on indoor hard courts. It was the fifth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Columbus, United States between 17 and 23 September 2018.