| 2018 Knoxville Challenger | |
|---|---|
| Date | 5–11 November |
| Edition | 15th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Reilly Opelka | |
| Doubles | |
 Toshihide Matsui /  Frederik Nielsen | |
The 2018 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the fifteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Knoxville, United States between 5 and 11 November 2018.