| 2019 Knoxville Challenger | |
|---|---|
| Date | 4–10 November |
| Edition | 16th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Michael Mmoh | |
| Doubles | |
 Hans Hach Verdugo /  Adrián Menéndez Maceiras | |
The 2019 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the sixteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Knoxville, United States between 4 and 10 November 2019.