| Event information | |
|---|---|
| Round 1 of 6 in the 2021 FIA World Endurance Championship | |
 | |
| Date | 1 May 2021 |
| Location | Stavelot |
| Venue | Circuit de Spa-Francorchamps |
| Duration | 6 hours |
| Results | |
| Laps completed | 162 |
| Distance (km) | 1134.648 |
| Distance (miles) | 705.024 |
| Hypercar | |
| Pole position | |
| Time | 2:00.747 |
| Team |  Toyota Gazoo Racing |
| Winners | |
| Team | Toyota Gazoo Racing |
| Drivers |  Sébastien Buemi Kazuki Nakajima Brendon Hartley |
| LMP2 | |
| Winners | |
| Team |  United Autosports USA |
| Drivers | Philip Hanson Fabio Scherer Filipe Albuquerque |
| LMP2 Pro-Am | |
| Winners | |
| Team |  Racing Team Nederland |
| Drivers | Frits van Eerd Giedo van der Garde Job van Uitert |
| LMGTE Pro | |
| Winners | |
| Team |  Porsche GT Team |
| Drivers |  Kévin Estre Neel Jani |
| LMGTE Am | |
| Winners | |
| Team |  AF Corse |
| Drivers | François Perrodo Nicklas Nielsen Alessio Rovera |
The 2021 Total 6 Hours of Spa-Francorchamps was an endurance sports car racing event held at the Circuit de Spa-Francorchamps, Stavelot, Belgium on 1 May 2021. It served as the opening round of the 2021 FIA World Endurance Championship, and was the tenth running of the event as part of the championship. The race marked the debut of the new 'Hypercar' era of endurance racing and was won by the debuting #8 Toyota GR010 Hybrid.