| Tournament details | |
|---|---|
| Dates | 26 November–20 December 2021 |
| Teams | 9 |
| Defending champions | Persemi Mimika |
| Final positions | |
| Champions | Toli[1] (1st title) |
| Runner-up | Persigubin Pegunungan Bintang |
| Third place | Persimer Merauke |
| Fourth place | Dogiyai |
The 2021 Liga 3 Papua was the fourth season of Liga 3 Papua as a qualifying round for the national round of the 2021–22 Liga 3.
Persemi Mimika were the defending champion.