| 2021 MUSC Health Women's Open | |
|---|---|
| Date | 12–18 April |
| Edition | 49th |
| Category | WTA 250 |
| Draw | 32S / 16D |
| Prize money | US$235,238 |
| Surface | Green clay |
| Location | Charleston, South Carolina, United States |
| Venue | Family Circle Tennis Center |
| Champions | |
| Singles | |
 Astra Sharma | |
| Doubles | |
 Hailey Baptiste / Caty McNally | |
The second 2021 Charleston Open (branded as the MUSC Health Women's Open for commercial reasons) was a tournament on the 2021 WTA Tour. It was played on outdoor green clay courts in Daniel Island. It was held one day after the 48th edition ended and was a replacement tournament for other tournaments that were not held because of travel restrictions, and organised by Charleston Tennis with a single-year licence in 2021, held at Family Circle Tennis Center from April 12 to 18, 2021.[1]
- ^ "MUSC Health Women's Open Overview". wtatennis.com.