| Dates | April 17 - August 1 |
|---|---|
| Champions | Milwaukee Bavarian SC (Western Conference) Detroit City U23 (Eastern Conference) |
| Matches played | 122 |
| Goals scored | 450 (3.69 per match) |
| Top goalscorer | Jordan Walker (FC Diablos) (15 goals) |
| Biggest home win | Milwaukee Bavarian SC 8-0 Union Dubuque (May 12) |
| Biggest away win | LK St.Clair 0-8 Lansing Common (Jul 11) |
| Highest scoring | LK St.Clair 2-7 Detroit City U23 (Jul 14) |
2022 → | |
The 2021 Midwest Premier League season has been the first season of the Midwest Premier League.
The season have seen 20 founder teams divided in two divisions and the two toppers of each division have been crowned champions. Milwaukee Bavarian SC have won the West Division and Detroit City U23 topped the East Division.