The 2021 FIM MotoGP World Championship was the premier class of the 73rd F.I.M. Road Racing World Championship season. Fabio Quartararo won his first world title, with five race wins ahead of securing the title in the third last race of the season. Quartararo became the first ever Frenchman to win the premier class title, which was also the first title for a non-Spanish rider since Australian Casey Stoner in 2011. The season also saw Francesco Bagnaia and Jorge Martín win their first premier class races. In the overall standings, Bagnaia secured second place and reigning champion Joan Mir secured third place, while Martín was named rookie of the year. Ducati secured the constructors' championship for the second consecutive season and the teams' championship for the first time since 2007. In total, eight different riders won Grands Prix during the season.
Six-time MotoGP champion Marc Márquez returned at the third race of the year after his arm and shoulder injury which had sidelined him from the 2020 season. Having initially struggled with the injury, the former champion won three races from summer onwards. It was also the final season of seven-time MotoGP title winner Valentino Rossi after 22 seasons in the premier class, as well as the final season in which a 500cc-era debutant participated in the premier class.