 | This article relies largely or entirely on a single source. (December 2020) |
| 2021 Murray River Open | |
|---|---|
| Date | 1–7 February |
| Edition | 1st |
| Category | ATP Tour 250 |
| Draw | 56S / 24D |
| Prize money | $320,775 |
| Surface | Hard |
| Location | Melbourne, Australia |
| Venue | Melbourne Park |
| Champions | |
| Singles | |
 Dan Evans | |
| Doubles | |
 Nikola Mektić / Mate Pavić | |
The 2021 Murray River Open was a tournament on the 2021 ATP Tour. It was played on outdoor hard courts in Melbourne, Australia. It was organised as a lead-up tournament to the 2021 Australian Open, and was held at the same venue, due to other tournaments in Australia being cancelled as a result from the COVID-19 pandemic. This tournament took place simultaneously with the 2021 Great Ocean Road Open and the 2021 ATP Cup.