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| Season | 2020–21 | ||||
|---|---|---|---|---|---|
| Teams | 64 | ||||
| Finals site | Alamodome San Antonio, Texas | ||||
| Champions | Stanford Cardinal (3rd title, 5th title game, 14th Final Four) | ||||
| Runner-up | Arizona Wildcats (1st title game, 1st Final Four) | ||||
| Semifinalists |
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| Winning coach | Tara VanDerveer (3rd title) | ||||
| MOP | Haley Jones (Stanford) | ||||
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The 2021 NCAA Division I women's basketball tournament was a single-elimination tournament of 64 teams to determine the National Collegiate Athletic Association (NCAA) Division I college basketball national champion for the 2020–21 NCAA Division I women's basketball season. The 39th edition of the tournament began on March 21, 2021, in sites around San Antonio, Texas, and concluded with the championship game on April 4 at the Alamodome, with the Stanford Cardinal defeating the Arizona Wildcats 54–53 to win their third NCAA title.
Due to logistical considerations surrounding the ongoing COVID-19 pandemic (which resulted in the cancellation of the 2020 tournament), and mirroring a similar decision by the men's tournament, the entire tournament was played in the San Antonio area rather than at sites across the country, with some first and second round games played in nearby San Marcos and Austin. The Alamodome hosted all games from the regional semifinals onward, including the originally-awarded Final Four and championship game.
Four schools, America East champion Stony Brook, Big South champion High Point, Missouri Valley champion Bradley and Utah Valley from the WAC (California Baptist won the WAC tournament, but was ineligible for the NCAA tournament because it is in the third year of a four-year transition from Division II), made their first appearance in the tournament.
Additionally, Tennessee continued its record streak of making every edition of the tournament. Arizona made its first-ever appearance in the Final Four. UConn extended its record streak of 13 consecutive Final Four appearances. Wake Forest and Washington State made their first appearances since 1988 and 1991, respectively.