| 2021 Next Generation ATP Finals | |
|---|---|
| Date | 9–13 November |
| Edition | 4th |
| Draw | 8S |
| Prize money | US$1,300,000 |
| Surface | Hard (indoor) |
| Location | Milan, Italy |
| Venue | PalaLido |
| Champions | |
 Carlos Alcaraz | |
The 2021 Next Generation ATP Finals (also known as the Intesa Sanpaolo Next Gen ATP Finals for sponsorship reasons) was a men's exhibition tennis tournament for the best singles players on the 2021 ATP Tour who were age 21 and under. It ran from 9 to 13 November 2021 in Milan, Italy at the PalaLido and was the fourth edition of the event.
Carlos Alcaraz defeated Sebastian Korda in the final, 4–3(7–5), 4–2, 4–2, to win the title. For the second consecutive occasion, the title was won by the youngest player in the draw.
Jannik Sinner was the defending champion from when the event was last held in 2019, but withdrew from the event before competition began.