| 2021 NPB season | |
|---|---|
| League | Nippon Professional Baseball |
| Sport | Baseball |
| Duration | March 26 – November 21 |
| Number of games | 143 |
| Number of teams | 12 |
| Central League Pennant | |
| League champions | Tokyo Yakult Swallows |
| Runners-up | Hanshin Tigers |
| Season MVP | Munetaka Murakami (Yakult) |
| Pacific League Pennant | |
| League champions | Orix Buffaloes |
| Runners-up | Chiba Lotte Marines |
| Season MVP | Yoshinobu Yamamoto (Orix) |
| Climax Series | |
| CL champions | Tokyo Yakult Swallows |
| CL runners-up | Yomiuri Giants |
| PL champions | Orix Buffaloes |
| PL runners-up | Chiba Lotte Marines |
| Japan Series | |
| Champions | Tokyo Yakult Swallows |
| Runners-up | Orix Buffaloes |
| Finals MVP | Yuhei Nakamura (Yakult) |
The 2021 Nippon Professional Baseball season was the 72nd season of professional baseball in Japan since Nippon Professional Baseball (NPB) was reorganized in 1950. There were 12 NPB teams, split evenly between the Central League and Pacific League.
Following the All-Star Series held on 16–17 July, the regular season went on hiatus in preparation for the 2020 Summer Olympics baseball tournament. The season resumed on 13 August. In the postseason, the Tokyo Yakult Swallows defeated the Orix Buffaloes in the Japan Series.