| 2021 Tennis Napoli Cup | |
|---|---|
| Date | 4–10 October |
| Edition | 20th |
| Surface | Clay |
| Location | Naples, Italy |
| Champions | |
| Singles | |
 Tallon Griekspoor | |
| Doubles | |
 Dustin Brown /  Andrea Vavassori | |
The 2021 Tennis Napoli Cup was a professional tennis tournament played on clay courts. It was the 20th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Naples, Italy between 4 and 10 October 2021.