| 2022 Columbus Challenger II | |
|---|---|
| Date | September 19–25 |
| Edition | 12th |
| Draw | 32S / 16D |
| Surface | Hard (indoor) |
| Location | Columbus, United States |
| Venue | Ohio State Varsity Tennis Center |
| Champions | |
| Singles | |
 Jordan Thompson | |
| Doubles | |
 Julian Cash / Henry Patten | |
The 2022 Columbus Challenger II was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the men's tournament which was part of the 2022 ATP Challenger Tour. It took place in Columbus, United States between September 19 and 25, 2022.