| 2022 Knoxville Challenger | |
|---|---|
| Date | 7–13 November |
| Edition | 18th |
| Surface | Hard (Indoor) |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Ben Shelton | |
| Doubles | |
| Hunter Reese / Tennys Sandgren | |
The 2022 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Knoxville, United States between 7 and 13 November 2022.