2F5 antibody

2F5 is a broadly neutralizing human monoclonal antibody (mAb) that has been shown to bind to and neutralize HIV-1 in vitro, making it a potential candidate for use in vaccine synthesis.[1][2] 2F5 recognizes an epitope in the membrane-proximal external region (MPER) of HIV-1 gp41. 2F5 then binds to this epitope and its constant region interacts with the viral lipid membrane, which neutralizes the virus.[3]

  1. ^ Muster, T.; Steindl, F.; Purtscher, M.; Trkola, A.; Klima, A.; Himmler, G.; Rüker, F.; Katinger, H. (1993-11-01). "A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1". Journal of Virology. 67 (11): 6642–6647. doi:10.1128/JVI.67.11.6642-6647.1993. ISSN 0022-538X. PMC 238102. PMID 7692082.
  2. ^ Shen, Xiaoying; Parks, Robert J.; Montefiori, David C.; Kirchherr, Jennifer L.; Keele, Brandon F.; Decker, Julie M.; Blattner, William A.; Gao, Feng; Weinhold, Kent J. (2009-04-15). "In Vivo gp41 Antibodies Targeting the 2F5 Monoclonal Antibody Epitope Mediate Human Immunodeficiency Virus Type 1 Neutralization Breadth". Journal of Virology. 83 (8): 3617–3625. doi:10.1128/JVI.02631-08. ISSN 0022-538X. PMC 2663270. PMID 19193787.
  3. ^ Ofek, Gilad; McKee, Krisha; Yang, Yongping; Yang, Zhi-Yong; Skinner, Jeff; Guenaga, F. Javier; Wyatt, Richard; Zwick, Michael B.; Nabel, Gary J. (2010-03-15). "Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region". Journal of Virology. 84 (6): 2955–2962. doi:10.1128/JVI.02257-09. ISSN 0022-538X. PMC 2826063. PMID 20042512.