| 2nd Destroyer Flotilla | |
|---|---|
| Active | January 1909–1943, 1945-1946 |
| Country |  United Kingdom |
| Branch |  Royal Navy |
| Size | Flotilla |
| Commanders | |
| First | Captain Edwyn Alexander-Sinclair |
| Last | Captain Bernard Armitage Warburton Warburton-Lee |
The British 2nd Destroyer Flotilla (also styled as Second Destroyer Flotilla) was a naval formation of the Royal Navy from 1909 to 1943 and again from 1945 to 1946.