4-aminobutyrate transaminase | |||||||||
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![]() 4-Aminobutyrate transaminase homodimer, Pig | |||||||||
Identifiers | |||||||||
EC no. | 2.6.1.19 | ||||||||
CAS no. | 9037-67-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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4-aminobutyrate transaminase | |||||||
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Identifiers | |||||||
Symbol | ABAT | ||||||
NCBI gene | 18 | ||||||
HGNC | 23 | ||||||
OMIM | 137150 | ||||||
RefSeq | NM_020686 | ||||||
UniProt | P80404 | ||||||
Other data | |||||||
Locus | Chr. 16 p13.2 | ||||||
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In enzymology, 4-aminobutyrate transaminase (EC 2.6.1.19), also called GABA transaminase or 4-aminobutyrate aminotransferase, or GABA-T, is an enzyme that catalyzes the chemical reaction:
Thus, the two substrates of this enzyme are 4-aminobutanoate (GABA) and 2-oxoglutarate. The two products are succinate semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-aminobutanoate:2-oxoglutarate aminotransferase. This enzyme participates in 5 metabolic pathways: alanine and aspartate metabolism, glutamate metabolism, beta-alanine metabolism, propanoate metabolism, and butanoate metabolism. It employs one cofactor, pyridoxal phosphate.
This enzyme is found in prokaryotes, plants, fungi, and animals (including humans).[1] Pigs have often been used when studying how this protein may work in humans.[2]