43S preinitiation complex

The 43S preinitiation complex (43S PIC) is a ribonucleoprotein complex that exists during an early step of eukaryotic translation initiation. The 43S PIC contains the small ribosomal subunit (40S) bound by the initiation factors eIF1, eIF1A, eIF3, and the eIF2-Met-tRNAiMet-GTP ternary complex (eIF2-TC).[1][2][3][4]

  1. ^ Sonenberg, Nahum; Hinnebusch, Alan G. (2009). "Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets". Cell. 136 (4). Elsevier BV: 731–745. doi:10.1016/j.cell.2009.01.042. ISSN 0092-8674. PMC 3610329. PMID 19239892.
  2. ^ Aitken, Colin E.; Lorsch, Jon R. (2012). "A mechanistic overview of translation initiation in eukaryotes". Nat. Struct. Mol. Biol. 19 (6): 568–576. doi:10.1038/nsmb.2303. PMID 22664984. S2CID 9201095.
  3. ^ Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114. Elsevier BV: 58–71. doi:10.1016/j.biochi.2015.02.017. ISSN 0300-9084. PMC 4458453. PMID 25742741.
  4. ^ Hinnebusch, Alan G. (2017). "Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation". Trends in Biochemical Sciences. 42 (8). Elsevier BV: 589–611. doi:10.1016/j.tibs.2017.03.004. ISSN 0968-0004. PMID 28442192.