4F2 cell-surface antigen heavy chain

SLC3A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DH2, 2DH3
Identifiers
Aliases	SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE, solute carrier family 3 member 2
External IDs	OMIM: 158070; MGI: 96955; HomoloGene: 1795; GeneCards: SLC3A2; OMA:SLC3A2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,888,880 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,700,733 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; ventricular zone; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; ganglionic eminence; ; upper lobe of left lung; ; skin of abdomen; ; canal of the cervix; ; skin of leg;
	Top expressed in
	epithelium of lens; ; choroid plexus of fourth ventricle; ; submandibular gland; ; parotid gland; ; calvaria; ; spermatocyte; ; stroma of bone marrow; ; right kidney; ; neural layer of retina; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium:sodium antiporter activity; neutral amino acid transmembrane transporter activity; catalytic activity; protein binding; double-stranded RNA binding; RNA binding; cadherin binding;
Cellular component	integral component of membrane; membrane; melanosome; plasma membrane; cell surface; apical plasma membrane; extracellular exosome; nucleus; cytosol;
Biological process	response to exogenous dsRNA; cell growth; amino acid transport; leukocyte migration; calcium ion transport; tryptophan transport; sodium ion transmembrane transport; L-alpha-amino acid transmembrane transport; transport; carbohydrate metabolic process; L-leucine import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6520
	17254
	ENSG00000168003
	ENSMUSG00000010095
	P08195
	P10852
NM_001012661; NM_001012662; NM_001012663; NM_001012664; NM_001013251;
	NM_002394
	NM_001161413; NM_008577
	NP_001012680; NP_001012682; NP_001013269; NP_002385
	NP_001154885; NP_032603
	Wikidata
View/Edit Human	View/Edit Mouse

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.^[5]^[6]

SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Teixeira S, Di Grandi S, Kühn LC (August 1987). "Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus". J Biol Chem. 262 (20): 9574–80. doi:10.1016/S0021-9258(18)47972-0. PMID 3036867.
^ "Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2".
^ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135. S2CID 19733993.
^ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038. S2CID 31954787.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168003 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3036867-5] Teixeira S, Di Grandi S, Kühn LC (August 1987). "Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus". J Biol Chem. 262 (20): 9574–80. doi:10.1016/S0021-9258(18)47972-0. PMID 3036867.

[entrez-6] "Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2".

[pmid15880135-7] Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135. S2CID 19733993.

[pmid16097038-8] Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038. S2CID 31954787.

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