5-HT1A receptor

HTR1A
Identifiers
Aliases	HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
External IDs	OMIM: 109760; MGI: 96273; HomoloGene: 20148; GeneCards: HTR1A; OMA:HTR1A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q12.3 Start 63,957,874 bp[1] End 63,962,507 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 56.92 cM Start 105,580,147 bp[2] End 105,584,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in entorhinal cortex middle temporal gyrus Brodmann area 46 superior vestibular nucleus superior frontal gyrus hippocampus proper prefrontal cortex endothelial cell Brodmann area 23 dorsolateral prefrontal cortex Top expressed in ventral nuclear group subthalamus ventral nucleus of lateral geniculate body ventral posterolateral nucleus ventral posteromedial nucleus medial habenular nucleus zona incerta lateral habenular nucleus thalamic reticular nucleus ventral lateral nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity G protein-coupled serotonin receptor activity protein binding serotonin binding neurotransmitter receptor activity receptor-receptor interaction Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane dendrite Biological process G protein-coupled receptor signaling pathway regulation of behavior vasoconstriction adenylate cyclase-inhibiting serotonin receptor signaling pathway serotonin metabolic process behavioral fear response regulation of dopamine metabolic process regulation of serotonin secretion exploration behavior serotonin receptor signaling pathway positive regulation of cell population proliferation regulation of hormone secretion cell population proliferation signal transduction animal behaviour G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3350 15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The serotonin 1A receptor (or 5-HT_1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A gene.^[5][6]