5-HT1B receptor

HTR1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IAQ, 4IAR
Identifiers
Aliases	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B
External IDs	OMIM: 182131; MGI: 96274; HomoloGene: 669; GeneCards: HTR1B; OMA:HTR1B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 77,460,924 bp[1] End 77,463,491 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 44.61 cM Start 81,510,344 bp[2] End 81,515,881 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery Descending thoracic aorta left coronary artery ascending aorta stromal cell of endometrium prefrontal cortex nucleus accumbens caudate nucleus Top expressed in ventral nuclear group ventral posteromedial nucleus nucleus accumbens ascending aorta lumbar spinal ganglion dorsal nucleus of lateral geniculate body subthalamus ventral posterolateral nucleus paraventricular nucleus of thalamus ventral lateral nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity G protein-coupled serotonin receptor activity protein binding neurotransmitter receptor activity serotonin binding voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Cellular component cytoplasm integral component of membrane membrane integral component of plasma membrane plasma membrane calyx of Held integral component of presynaptic membrane serotonergic synapse dendrite Biological process chemical synaptic transmission G protein-coupled receptor internalization regulation of dopamine secretion regulation of behavior response to mineralocorticoid vasoconstriction adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cellular response to alkaloid negative regulation of serotonin secretion cellular response to temperature stimulus negative regulation of synaptic transmission, GABAergic protein kinase C-activating G protein-coupled receptor signaling pathway drinking behavior bone remodeling feeding behavior response to ethanol negative regulation of synaptic transmission, glutamatergic signal transduction response to cocaine positive regulation of vascular associated smooth muscle cell proliferation G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway animal behaviour presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis regulation of presynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3351 15551 Ensembl ENSG00000135312 ENSMUSG00000049511 UniProt P28222 P28334 RefSeq (mRNA) NM_000863 NM_010482 RefSeq (protein) NP_000854 NP_034612 Location (UCSC) Chr 6: 77.46 – 77.46 Mb Chr 9: 81.51 – 81.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5-hydroxytryptamine receptor 1B also known as the 5-HT_1B receptor is a protein that in humans is encoded by the HTR1B gene.^[5][6] The 5-HT_1B receptor is a 5-HT receptor subtype.^[7]