5-HT1F receptor

HTR1F
Identifiers
Aliases	HTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F receptor, 5-hydroxytryptamine receptor 1F
External IDs	OMIM: 182134; MGI: 99842; HomoloGene: 37361; GeneCards: HTR1F; OMA:HTR1F - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	87,993,839 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	64,926,217 bp
RNA expression pattern
	Top expressed in
	testicle; ; islet of Langerhans; ; Achilles tendon; ; gonad; ; prefrontal cortex; ; smooth muscle tissue; ; subcutaneous adipose tissue; ; primary visual cortex; ; cervix; ; mononuclear cell;
	Top expressed in
	lumbar spinal ganglion; ; paraventricular nucleus of thalamus; ; ventral nucleus of lateral geniculate body; ; subthalamus; ; ventral nuclear group; ; multiform layer of neocortex; ; lateral preoptic nucleus; ; ventral lateral nucleus; ; internal pyramidal layer of neocortex; ; thalamic reticular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; serotonin binding; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; dendrite;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; signal transduction; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3355
	15557
	ENSG00000179097
	ENSMUSG00000050783
	P30939
	Q02284
	NM_000866; NM_001322208; NM_001322209; NM_001322210
	NM_008310
	NP_000857; NP_001309137; NP_001309138; NP_001309139
	NP_032336
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.^[5]^[6]^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179097 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050783 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.
^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.
^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179097 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050783 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".

[pmid8380639-6] Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.

[pmid8384716-7] Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.

[pmid9394293-8] Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.

[pmid9632173-9] Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.

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