5-HT4 receptor

HTR4
Identifiers
Aliases	HTR4, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
External IDs	OMIM: 602164; MGI: 109246; HomoloGene: 20243; GeneCards: HTR4; OMA:HTR4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	148,677,235 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	62,629,648 bp
RNA expression pattern
	Top expressed in
	beta cell; ; triceps brachii muscle; ; glutes; ; testicle; ; external globus pallidus; ; vena cava; ; vastus lateralis muscle; ; pars reticulata; ; pars compacta; ; epithelium of nasopharynx;
	Top expressed in
	lumbar spinal ganglion; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; olfactory tubercle; ; left colon; ; Paneth cell; ; Region I of hippocampus proper; ; CA3 field; ; perirhinal cortex; ; intestinal villus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; trace-amine receptor activity; identical protein binding; neurotransmitter receptor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; endosome; plasma membrane; integral component of plasma membrane; membrane; dendrite;
Biological process	gamma-aminobutyric acid signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; regulation of appetite; signal transduction; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3360
	15562
	ENSG00000164270
	ENSMUSG00000026322
	Q13639
	P97288
NM_000870; NM_001040169; NM_001040172; NM_001040173; NM_001040174;
	NM_001286410; NM_199453
	NM_008313; NM_001364956; NM_001364957; NM_001364958; NM_001364959
NP_000861; NP_001035259; NP_001035262; NP_001035263; NP_001273339;
	NP_955525
	NP_032339; NP_001351885; NP_001351886; NP_001351887; NP_001351888
	Wikidata
View/Edit Human	View/Edit Mouse

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164270 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026322 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S (December 1997). "Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31→q33 by in situ hybridization" (PDF). Cytogenetics and Cell Genetics. 78 (2): 133–4. doi:10.1159/000134646. PMID 9371406.
^ Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R (August 1997). "Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium". FEBS Letters. 412 (3): 465–74. doi:10.1016/S0014-5793(97)00820-X. PMID 9276448. S2CID 23714426.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164270 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026322 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9371406-5] Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S (December 1997). "Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31→q33 by in situ hybridization" (PDF). Cytogenetics and Cell Genetics. 78 (2): 133–4. doi:10.1159/000134646. PMID 9371406.

[pmid9276448-6] Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R (August 1997). "Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium". FEBS Letters. 412 (3): 465–74. doi:10.1016/S0014-5793(97)00820-X. PMID 9276448. S2CID 23714426.

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