5-HT5A receptor

HTR5A
Identifiers
Aliases	HTR5A, 5-HT5A, 5-HT5A receptor, 5-hydroxytryptamine receptor 5A
External IDs	OMIM: 601305; MGI: 96283; HomoloGene: 22461; GeneCards: HTR5A; OMA:HTR5A - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	155,087,392 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	28,060,086 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; secondary oocyte; ; hypothalamus; ; nucleus accumbens; ; superior frontal gyrus;
	Top expressed in
	secondary oocyte; ; intestinal villus; ; Ileal epithelium; ; zygote; ; lumbar subsegment of spinal cord; ; choroid plexus of fourth ventricle; ; perirhinal cortex; ; entorhinal cortex; ; gastrula; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; serotonin binding;
Cellular component	integral component of membrane; perikaryon; plasma membrane; rough endoplasmic reticulum; Golgi apparatus; integral component of plasma membrane; membrane; dendrite; integral component of postsynaptic specialization membrane;
Biological process	G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; brain development; response to estradiol; hippocampus development; cAMP-mediated signaling; signal transduction; adenylate cyclase-inhibiting serotonin receptor signaling pathway; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	3361
	15563
	ENSG00000157219
	ENSMUSG00000039106
	P47898
	P30966
	NM_024012
	NM_008314
	NP_076917
	NP_032340
	Wikidata
View/Edit Human	View/Edit Mouse

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.^[5]^[6] Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039106 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HTR5A 5-hydroxytryptamine (serotonin) receptor 5A".
^ Rees S, den Daas I, Foord S, Goodson S, Bull D, Kilpatrick G, Lee M (December 1994). "Cloning and characterisation of the human 5-HT5A serotonin receptor". FEBS Letters. 355 (3): 242–246. doi:10.1016/0014-5793(94)01209-1. PMID 7988681. S2CID 36425845.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039106 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HTR5A 5-hydroxytryptamine (serotonin) receptor 5A".

[pmid7988681-6] Rees S, den Daas I, Foord S, Goodson S, Bull D, Kilpatrick G, Lee M (December 1994). "Cloning and characterisation of the human 5-HT5A serotonin receptor". FEBS Letters. 355 (3): 242–246. doi:10.1016/0014-5793(94)01209-1. PMID 7988681. S2CID 36425845.

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