5-lipoxygenase-activating protein

ALOX5AP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q7R, 2Q7M
Identifiers
Aliases	ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating protein
External IDs	OMIM: 603700; MGI: 107505; HomoloGene: 1231; GeneCards: ALOX5AP; OMA:ALOX5AP - orthologs
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	149,224,963 bp
RNA expression pattern
	Top expressed in
	blood; ; trabecular bone; ; bone marrow; ; right lung; ; bone marrow cells; ; monocyte; ; upper lobe of left lung; ; spleen; ; lower lobe of lung; ; periodontal fiber;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; right lung lobe; ; ankle; ; interventricular septum; ; carotid body; ; spleen; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutathione transferase activity; protein N-terminus binding; leukotriene-C4 synthase activity; glutathione peroxidase activity; protein binding; arachidonic acid binding; enzyme activator activity;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; nuclear envelope; endoplasmic reticulum; nucleus;
Biological process	cellular response to calcium ion; leukotriene metabolic process; positive regulation of catalytic activity; protein homotrimerization; lipoxygenase pathway; leukotriene biosynthetic process; lipoxin metabolic process; cellular oxidant detoxification; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	241
	11690
	n/a
	ENSMUSG00000060063
	P20292
	P30355
	NM_001204406; NM_001629
	NM_009663; NM_001308462
	NP_001191335; NP_001620
	NP_001295391; NP_033793
	Wikidata
View/Edit Human	View/Edit Mouse

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.^[4]^[5]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060063 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kennedy BP, Diehl RE, Boie Y, Adam M, Dixon RA (May 1991). "Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)". The Journal of Biological Chemistry. 266 (13): 8511–6. doi:10.1016/S0021-9258(18)93004-8. PMID 1673682.
^ Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM (February 1999). "Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12". Genomics. 56 (1): 131–3. doi:10.1006/geno.1998.5651. PMID 10036194.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000060063 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1673682-4] Kennedy BP, Diehl RE, Boie Y, Adam M, Dixon RA (May 1991). "Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)". The Journal of Biological Chemistry. 266 (13): 8511–6. doi:10.1016/S0021-9258(18)93004-8. PMID 1673682.

[pmid10036194-5] Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM (February 1999). "Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12". Genomics. 56 (1): 131–3. doi:10.1006/geno.1998.5651. PMID 10036194.

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