5S ribosomal RNA

5S ribosomal RNA
Predicted secondary structure and sequence conservation of 5S ribosomal RNA
Identifiers
Symbol5S_rRNA
RfamRF00001 CL00113
Other data
RNA typeGene; rRNA
Domain(s)Eukaryota; Bacteria; Archaea
GOGO:0005840 GO:0003735
SOSO:0000652
PDB structuresPDBe

The 5S ribosomal RNA (5S rRNA) is an approximately 120 nucleotide-long ribosomal RNA molecule with a mass of 40 kDa. It is a structural and functional component of the large subunit of the ribosome in all domains of life (bacteria, archaea, and eukaryotes), with the exception of mitochondrial ribosomes of fungi and animals. The designation 5S refers to the molecule's sedimentation coefficient in an ultracentrifuge, which is measured in Svedberg units (S).[1]

Figure 1: A 3D representation of a 5S rRNA molecule. This structure is of the 5S rRNA from the Escherichia coli 50S ribosomal subunit and is based on a cryo-electron microscopic reconstruction.[2]
  1. ^ Szymanski M, Barciszewska MZ, Erdmann VA, Barciszewski J (January 2002). "5S Ribosomal RNA Database". Nucleic Acids Research. 30 (1): 176–178. doi:10.1093/nar/30.1.176. PMC 99124. PMID 11752286.
  2. ^ Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, et al. (April 2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution". Journal of Molecular Biology. 298 (1): 35–59. doi:10.1006/jmbi.2000.3635. PMID 10756104.