A. Hari Reddi

A. Hari Reddi
Born
A. Hari Reddi

(1942-10-20) October 20, 1942 (age 81)
Chennai, India
Alma materUniversity of Delhi
OccupationBiologist
Known forBone morphogenetic protein
Extracellular matrix
Tissue Engineering
AwardsMarshall R. Urist Award
Scientific career
InstitutionsUniversity of California
Johns Hopkins University
National Institutes of Health
University of Chicago

A. Hari Reddi (born October 20, 1942) is a University of California Distinguished Professor and holder of the Lawrence J. Ellison Endowed Chair in Musculoskeletal Molecular Biology at the University of California, Davis.[1] His research played an indispensable role in the identification, isolation and purification of bone morphogenetic proteins (BMPs) that are involved in bone formation and repair.[2][3]

The molecular mechanism of bone induction studied by Professor Reddi led to the conceptual advance in tissue engineering that morphogens in the form of metabologens bound to an insoluble extracellular matrix scaffolding act in collaboration to stimulate stem cells to form cartilage and bone.[4][5][6] The Reddi laboratory has also made important discoveries unraveling the role of the extracellular matrix in bone and cartilage tissue regeneration and repair.[7][8][9][10]

Professor Reddi was previously the Virginia M. and William A. Percy Chair and Professor in Orthopaedic Surgery, Professor of Biological Chemistry, and Professor of Oncology at the Johns Hopkins University School of Medicine.[11] He also past faculty member at the University of Chicago and senior scientist at the National Institutes of Health.[12]

  1. ^ "Dr. A. Hari Reddi, M.S., Ph.D. For UC Davis Health".
  2. ^ Scientists Succeed In Growing Bone, The New York Times, Oct. 22, 1996
  3. ^ Hopkins grows its own bone orchard, The Baltimore Sun, Jan. 24, 1992
  4. ^ Khouri R, Koudsi B, Reddi H. Tissue Transformation Into Bone In Vivo: A Potential Practical Application. Journal of the American Medical Association JAMA. 1991;266(14):1953-1955
  5. ^ Sampath TK, Nathanson MA, Reddi AH. In vitro transformation of mesenchymal cells derived from embryonic muscle into cartilage in response to extracellular matrix components of bone. Proc Natl Acad Sci U S A 1984; 81:3419-23.
  6. ^ Muscle Is Turned Into Bone By Researchers in St. Louis, The New York Times, Oct. 9, 1991
  7. ^ Reddi AH, Gay R, Gay S, Miller EJ. Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 1977; 74:5589-92.
  8. ^ Weiss RE, Reddi AH. Synthesis and localization of fibronectin during collagenous matrix- mesenchymal cell interaction and differentiation of cartilage and bone in vivo. Proc Natl Acad Sci U S A 1980; 77:2074-8.
  9. ^ Sampath TK, Reddi AH. Importance of geometry of the extracellular matrix in endochondral bone differentiation. J Cell Biol 1984; 98:2192-7.
  10. ^ Vukicevic S, Luyten FP, Kleinman HK, Reddi AH. Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: regulation by discrete domains of laminin. Cell 1990; 63:437-45.
  11. ^ "Johns Hopkins Gazette: April 15, 1996".
  12. ^ Furchgott, Roy (1993-04-04). "Technology; Urging the Bones to Heal". The New York Times. ISSN 0362-4331. Retrieved 2024-07-28.