A2ML1

A2ML1
Identifiers
Aliases	A2ML1, CPAMD9, alpha-2-macroglobulin like 1, p170, OMS
External IDs	OMIM: 610627; HomoloGene: 67167; GeneCards: A2ML1; OMA:A2ML1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,887,001 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; mucosa of pharynx; ; oral cavity; ; body of tongue; ; human penis; ; skin of abdomen; ; skin of leg; ; buccal mucosa cell; ; vulva;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; peptidase inhibitor activity;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	negative regulation of endopeptidase activity; negative regulation of peptidase activity; regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	144568
	n/a
	ENSG00000166535
	n/a
	A8K2U0; H0YGG5
	n/a
	NM_001282424; NM_144670
	n/a
	NP_001269353; NP_653271
	n/a
	Wikidata
View/Edit Human

Alpha-2-macroglobulin-like 1 abbreviated as α2ML1 is a protein that in humans is encoded by the A2ML1 gene.^[3] α2ML1 is a large, 180 kDa protein found in the epidermis. It is able to the inhibit the chymotryptic activity of KLK7.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166535 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Alpha-2-macroglobulin-like 1".
^ Galliano MF, Toulza E, Gallinaro H, Jonca N, Ishida-Yamamoto A, Serre G, Guerrin M (November 2005). "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis". J Biol Chem. 281 (9): 5780–5789. doi:10.1074/jbc.m508017200. PMID 16298998.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166535 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Alpha-2-macroglobulin-like 1".

[a2mg1-4] Galliano MF, Toulza E, Gallinaro H, Jonca N, Ishida-Yamamoto A, Serre G, Guerrin M (November 2005). "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis". J Biol Chem. 281 (9): 5780–5789. doi:10.1074/jbc.m508017200. PMID 16298998.

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