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| Route information | ||||
| Major junctions | ||||
| South end | Luton 51°52′42″N 0°24′29″W / 51.8782°N 0.4080°W | |||
 A421
 A7 | ||||
| North end | Carlisle 54°53′43″N 2°55′52″W / 54.8954°N 2.9311°W | |||
| Location | ||||
| Country | United Kingdom | |||
| Constituent country | England | |||
| Primary destinations | Bedford Kettering Market Harborough Leicester Loughborough Derby Matlock Buxton Stockport Manchester Preston Lancaster Kendal Penrith | |||
| Road network | ||||
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The A6 is one of the main north–south roads in England. It runs from Luton in Bedfordshire to Carlisle in Cumbria, although it formerly started at a junction with the A1 at Barnet in north London, and is described as running from London to Carlisle.
Running north-west from Luton, the road passes through Bedford, bypasses Rushden, Kettering and Market Harborough, continues through Leicester, Loughborough, Derby and Matlock before passing through the Peak District to Bakewell, Buxton, Stockport, Manchester, Salford, Chorley, Preston, Lancaster, Kendal and Penrith before reaching Carlisle.
South of Derby, the road runs approximately parallel to the M1 motorway; between Manchester and Preston, it is close to the M6 and M61 motorways; and from Preston to its northern terminus in Carlisle, it is close to the M6.