ABAT

ABAT
Identifiers
Aliases	ABAT, Abat, 9630038C02Rik, AI255750, ENSMUSG00000051226, Gabaat, Gabat, Gm9851, I54, Laibat, X61497, GABA-AT, NPD009, 4-aminobutyrate aminotransferase
External IDs	OMIM: 137150; MGI: 2443582; HomoloGene: 542; GeneCards: ABAT; OMA:ABAT - orthologs
EC number	2.6.1.22
Gene location (Human)
Chr.	Chromosome 16 (human)
End	8,784,575 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	8,439,432 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; entorhinal cortex; ; postcentral gyrus; ; external globus pallidus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus;
	Top expressed in
	nucleus accumbens; ; left lobe of liver; ; central gray substance of midbrain; ; globus pallidus; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; lateral hypothalamus; ; deep cerebellar nuclei; ; arcuate nucleus; ; nucleus of stria terminalis;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; 4-aminobutyrate transaminase activity; protein homodimerization activity; transaminase activity; iron-sulfur cluster binding; metal ion binding; succinate-semialdehyde dehydrogenase binding; catalytic activity; (S)-3-amino-2-methylpropionate transaminase activity; pyridoxal phosphate binding; 4-aminobutyrate:2-oxoglutarate transaminase activity;
Cellular component	4-aminobutyrate transaminase complex; mitochondrial matrix; neuron projection; mitochondrion;
Biological process	positive regulation of dopamine metabolic process; positive regulation of aspartate secretion; response to cocaine; gamma-aminobutyric acid biosynthetic process; response to hypoxia; locomotory behavior; behavioral response to cocaine; negative regulation of blood pressure; positive regulation of inhibitory postsynaptic potential; response to nicotine; ageing; gamma-aminobutyric acid metabolic process; negative regulation of platelet aggregation; cerebellum development; copulation; neurotransmitter catabolic process; response to iron ion; negative regulation of gamma-aminobutyric acid secretion; exploration behavior; positive regulation of heat generation; negative regulation of dopamine secretion; response to ethanol; positive regulation of uterine smooth muscle contraction; positive regulation of insulin secretion; positive regulation of prolactin secretion; gamma-aminobutyric acid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	18
	268860
	ENSG00000183044
	ENSMUSG00000057880
	P80404
	P61922
	NM_000663; NM_001127448; NM_020686
	NM_001170978; NM_172961
	NP_000654; NP_001120920; NP_065737
	NP_001164449; NP_766549
	Wikidata
View/Edit Human	View/Edit Mouse

4-Aminobutyrate aminotransferase is a protein that in humans is encoded by the ABAT gene.^[5] This gene is located in chromosome 16 at position of 13.2.^[6] This gene goes by a number of names, including, GABA transaminase, GABAT, 4-aminobutyrate transaminase, NPD009 etc.^[6] This gene is mainly and abundant located in neuronal tissues.^[7] 4-Aminobutyrate aminotransferase belongs to group of pyridoxal 5-phosphate-dependent enzyme which activates a large portion giving reaction to amino acids.^[8] ABAT is made up of two monomers of enzymes where each subunit has a molecular weight of 50kDa.^[9] It is identified that almost tierce of human synapses have GABA.^[6] GABA is a neurotransmitter that has different roles in different regions of the central and peripheral nervous systems. It can be found also in some tissues that do not have neurons.^[6] In addition, GAD and GABA-AT are responsible in regulating the concentration of GABA.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183044 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: 4-aminobutyrate aminotransferase".
^ ^a ^b ^c ^d Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002). "GABA and GABA receptors in the central nervous system and other organs". International Review of Cytology. 213. Elsevier: 1–47. doi:10.1016/s0074-7696(02)13011-7. ISBN 9780123646170. PMID 11837891.
^ Jirholt J, Asling B, Hammond P, Davidson G, Knutsson M, Walentinsson A, Jensen JM, Lehmann A, Agreus L, Lagerström-Fermer M (April 2011). "4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease". PLOS ONE. 6 (4): e19095. Bibcode:2011PLoSO...619095J. doi:10.1371/journal.pone.0019095. PMC 3084265. PMID 21552517.
^ Markova M, Peneff C, Hewlins MJ, Schirmer T, John RA (October 2005). "Determinants of substrate specificity in omega-aminotransferases". The Journal of Biological Chemistry. 280 (43): 36409–16. doi:10.1074/jbc.m506977200. PMID 16096275.
^ Churchich JE (September 1982). "4-Aminobutyrate aminotransferase. Different susceptibility to inhibitors, microenvironment of the cofactor binding site and distance of the catalytic sites". European Journal of Biochemistry. 126 (3): 507–11. doi:10.1111/j.1432-1033.1982.tb06809.x. PMID 7140743.
^ Tovar-Gudiño E, Guevara-Salazar JA, Bahena-Herrera JR, Trujillo-Ferrara JG, Martínez-Campos Z, Razo-Hernández RS, Santiago Á, Pastor N, Fernández-Zertuche M (May 2018). "Pseudomonas fluorescens and In Silico Molecular Modeling". Molecules. 23 (5): 1128. doi:10.3390/molecules23051128. PMC 6099672. PMID 29747438.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183044 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: 4-aminobutyrate aminotransferase".

[:0-6] Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002). "GABA and GABA receptors in the central nervous system and other organs". International Review of Cytology. 213. Elsevier: 1–47. doi:10.1016/s0074-7696(02)13011-7. ISBN 9780123646170. PMID 11837891.

[:1-7] Jirholt J, Asling B, Hammond P, Davidson G, Knutsson M, Walentinsson A, Jensen JM, Lehmann A, Agreus L, Lagerström-Fermer M (April 2011). "4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease". PLOS ONE. 6 (4): e19095. Bibcode:2011PLoSO...619095J. doi:10.1371/journal.pone.0019095. PMC 3084265. PMID 21552517.

[8] Markova M, Peneff C, Hewlins MJ, Schirmer T, John RA (October 2005). "Determinants of substrate specificity in omega-aminotransferases". The Journal of Biological Chemistry. 280 (43): 36409–16. doi:10.1074/jbc.m506977200. PMID 16096275.

[9] Churchich JE (September 1982). "4-Aminobutyrate aminotransferase. Different susceptibility to inhibitors, microenvironment of the cofactor binding site and distance of the catalytic sites". European Journal of Biochemistry. 126 (3): 507–11. doi:10.1111/j.1432-1033.1982.tb06809.x. PMID 7140743.

[:2-10] Tovar-Gudiño E, Guevara-Salazar JA, Bahena-Herrera JR, Trujillo-Ferrara JG, Martínez-Campos Z, Razo-Hernández RS, Santiago Á, Pastor N, Fernández-Zertuche M (May 2018). "Pseudomonas fluorescens and In Silico Molecular Modeling". Molecules. 23 (5): 1128. doi:10.3390/molecules23051128. PMC 6099672. PMID 29747438.

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