ABCC4

ABCC4
Identifiers
Aliases	ABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4
External IDs	OMIM: 605250; MGI: 2443111; HomoloGene: 74563; GeneCards: ABCC4; OMA:ABCC4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	95,301,475 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	118,943,631 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; secondary oocyte; ; buccal mucosa cell; ; corpus epididymis; ; kidney tubule; ; mucosa of urinary bladder; ; Epithelium of choroid plexus; ; epithelium of nasopharynx; ; mucosa of sigmoid colon; ; stromal cell of endometrium;
	Top expressed in
	transitional epithelium of urinary bladder; ; conjunctival fornix; ; Epithelium of choroid plexus; ; olfactory epithelium; ; lacrimal gland; ; iris; ; ciliary body; ; retinal pigment epithelium; ; cornea; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATPase-coupled inorganic anion transmembrane transporter activity; P-type ion transporter activity; ATPase-coupled transmembrane transporter activity; protein binding;
Cellular component	integral component of membrane; platelet dense granule membrane; membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane;
Biological process	prostaglandin secretion; platelet degranulation; response to organic cyclic compound; response to organic substance; positive regulation of smooth muscle cell proliferation; response to organonitrogen compound; transmembrane transport; cilium assembly; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10257
	239273
	ENSG00000125257
	ENSMUSG00000032849
	O15439
	E9Q236
	NM_001105515; NM_001301829; NM_001301830; NM_005845
	NM_001033336; NM_001163675; NM_001163676
	NP_001098985; NP_001288758; NP_001288759; NP_005836
	NP_001028508; NP_001157147; NP_001157148
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.^[5]^[6]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.^[7] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.^[8]

MRP4/ABCC4 expression is dysregulated in several cancers ^[9]^[10]^[11] and is also upregulated in peritoneal endometriosis.^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032849 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ATP-binding cassette".
^ Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Research. 58 (13): 2741–7. PMID 9661885.
^ Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". The Journal of Clinical Investigation. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120.
^ Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, et al. (2003). "The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs". Proc Natl Acad Sci U S A. 100 (16): 9244–9. Bibcode:2003PNAS..100.9244R. doi:10.1073/pnas.1033060100. PMC 170903. PMID 12835412.
^ Ho LL, Kench JG, Handelsman DJ, Scheffer GL, Stricker PD, Grygiel JG, et al. (2008). "Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer". Prostate. 68 (13): 1421–9. doi:10.1002/pros.20809. PMID 18615486. S2CID 42717909.
^ Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, et al. (2011). "Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation". J Biol Chem. 286 (9): 6979–88. doi:10.1074/jbc.m110.166868. PMC 3044954. PMID 21205825.
^ Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.
^ Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2013). "Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)". Fertil Steril. 99 (7): 1965–1973.e2. doi:10.1016/j.fertnstert.2013.01.146. PMID 23472950.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032849 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ATP-binding cassette".

[pmid9661885-6] Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Research. 58 (13): 2741–7. PMID 9661885.

[pmid18636120-7] Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". The Journal of Clinical Investigation. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120.

[8] Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, et al. (2003). "The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs". Proc Natl Acad Sci U S A. 100 (16): 9244–9. Bibcode:2003PNAS..100.9244R. doi:10.1073/pnas.1033060100. PMC 170903. PMID 12835412.

[9] Ho LL, Kench JG, Handelsman DJ, Scheffer GL, Stricker PD, Grygiel JG, et al. (2008). "Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer". Prostate. 68 (13): 1421–9. doi:10.1002/pros.20809. PMID 18615486. S2CID 42717909.

[10] Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, et al. (2011). "Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation". J Biol Chem. 286 (9): 6979–88. doi:10.1074/jbc.m110.166868. PMC 3044954. PMID 21205825.

[11] Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.

[12] Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2013). "Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)". Fertil Steril. 99 (7): 1965–1973.e2. doi:10.1016/j.fertnstert.2013.01.146. PMID 23472950.

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