ABCE1

ABCE1
Identifiers
Aliases	ABCE1, ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I, ATP binding cassette subfamily E member 1, RLI1
External IDs	OMIM: 601213; MGI: 1195458; HomoloGene: 2205; GeneCards: ABCE1; OMA:ABCE1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	145,129,524 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	80,438,369 bp
RNA expression pattern
	Top expressed in
	gonad; ; islet of Langerhans; ; ventricular zone; ; Achilles tendon; ; stromal cell of endometrium; ; testicle; ; ganglionic eminence; ; secondary oocyte; ; body of pancreas; ; rectum;
	Top expressed in
	epiblast; ; cumulus cell; ; abdominal wall; ; Gonadal ridge; ; lacrimal gland; ; maxillary prominence; ; mandibular prominence; ; dermis; ; primitive streak; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; iron ion binding; ribosomal small subunit binding; ATP binding; endoribonuclease inhibitor activity;
Cellular component	cytoplasm; mitochondrial matrix; membrane; mitochondrion; eukaryotic translation initiation factor 3 complex; cytosol;
Biological process	viral process; ribosomal subunit export from nucleus; translational termination; negative regulation of endoribonuclease activity; translational initiation; regulation of type I interferon-mediated signaling pathway; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	6059
	24015
	ENSG00000164163
	ENSMUSG00000058355
	P61221
	P61222
	NM_002940; NM_001040876
	NM_015751
	NP_001035809; NP_002931
	NP_056566
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene.

ABCE1 is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily.^[5]

ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L,^[6] and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.^[7]

ABCE1 is an essential and highly conserved protein that is required for both eukaryotic translation initiation as well as ribosome biogenesis. The most studied homologues are Rli1p in yeast and Pixie in Drosophila.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164163 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 [ Homo sapiens ]". Retrieved 14 March 2013.
^ "P61221 (ABCE1_HUMAN)".
^ Tian Y, Han X, Tian DL (October 2012). "The biological regulation of ABCE1". IUBMB Life. 64 (10): 795–800. doi:10.1002/iub.1071. PMID 23008114. S2CID 21490502.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164163 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 [ Homo sapiens ]". Retrieved 14 March 2013.

[6] "P61221 (ABCE1_HUMAN)".

[7] Tian Y, Han X, Tian DL (October 2012). "The biological regulation of ABCE1". IUBMB Life. 64 (10): 795–800. doi:10.1002/iub.1071. PMID 23008114. S2CID 21490502.

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