ABL (gene)

ABL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
External IDsOMIM: 189980; MGI: 87859; HomoloGene: 3783; GeneCards: ABL1; OMA:ABL1 - orthologs
EC number2.7.10.2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007313
NM_005157

NM_001112703
NM_009594
NM_001283045
NM_001283046
NM_001283047

RefSeq (protein)

NP_005148
NP_009297

NP_001106174
NP_001269974
NP_001269975
NP_001269976
NP_033724

Location (UCSC)Chr 9: 130.71 – 130.89 MbChr 2: 31.58 – 31.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.[5] c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000097007Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026842Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–5. Bibcode:1991Sci...253..562S. doi:10.1126/science.1857987. PMID 1857987.
  6. ^ Abelson HT, Rabstein LS (August 1970). "Lymphosarcoma: virus-induced thymic-independent disease in mice". Cancer Research. 30 (8): 2213–22. PMID 4318922.