| Ernest F. Hollings ACE Basin National Wildlife Refuge | |
|---|---|
IUCN category IV (habitat/species management area) | |
 Rice trunk at ACE Basin NWR | |
  Map of the United States  ACE Basin National Wildlife Refuge (South Carolina) | |
| Location | Beaufort, Charleston, Colleton, Hampton counties, South Carolina, United States |
| Nearest city | Beaufort, South Carolina |
| Coordinates | 32°30′30″N 80°28′00″W / 32.50833°N 80.46667°W |
| Area | 11,815 acres (47.81 km2) |
| Established | 1990 |
| Governing body | U.S. Fish and Wildlife Service |
| Website | Ernest F. Hollings ACE Basin National Wildlife Refuge |
The Ernest F. Hollings ACE Basin National Wildlife Refuge is a 11,815-acre (47.81 km2) portion of the larger ACE Basin area, and the only portions that are federally protected. The wildlife refuge is divided into two units: the Edisto River unit and the Combahee River unit.
The following threatened or endangered species are present in the refuge: wood stork