ACO1

ACO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B3X, 2B3Y
Identifiers
Aliases	ACO1, ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1, aconitase 1
External IDs	OMIM: 100880; MGI: 87879; HomoloGene: 1657; GeneCards: ACO1; OMA:ACO1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	32,454,769 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	40,198,338 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; stromal cell of endometrium; ; right adrenal gland; ; right adrenal cortex; ; adipose tissue; ; left adrenal gland; ; kidney tubule; ; subcutaneous adipose tissue; ; duodenum; ; jejunal mucosa;
	Top expressed in
	tunica adventitia of aorta; ; external carotid artery; ; internal carotid artery; ; migratory enteric neural crest cell; ; dermis; ; efferent ductule; ; carotid body; ; tunica media of zone of aorta; ; submandibular gland; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron-sulfur cluster binding; metal ion binding; protein binding; lyase activity; RNA binding; aconitate hydratase activity; iron-responsive element binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding;
Cellular component	Golgi apparatus; endoplasmic reticulum; mitochondrion; extracellular exosome; cytoplasm; cytosol;
Biological process	response to iron(II) ion; tricarboxylic acid cycle; post-embryonic development; regulation of gene expression; intestinal absorption; metabolism; regulation of translation; citrate metabolic process; cellular iron ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	48
	11428
	ENSG00000122729
	ENSMUSG00000028405
	P21399
	P28271
	NM_001278352; NM_002197; NM_001362840
	NM_007386
	NP_001265281; NP_002188; NP_001349769
	NP_031412
	Wikidata
View/Edit Human	View/Edit Mouse

Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122729 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Aconitase 1, soluble".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122729 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Aconitase 1, soluble".

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