ACOT2

ACOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HLK
Identifiers
Aliases	ACOT2, CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128, acyl-CoA thioesterase 2
External IDs	OMIM: 609972; MGI: 2159605; HomoloGene: 25661; GeneCards: ACOT2; OMA:ACOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	73,575,658 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,040,647 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; liver; ; left ventricle; ; right lobe of liver; ; muscle of thigh; ; skeletal muscle tissue; ; gastrocnemius muscle; ; right auricle; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	interventricular septum; ; aortic valve; ; myocardium of ventricle; ; ascending aorta; ; muscle of thigh; ; brown adipose tissue; ; cumulus cell; ; ciliary body; ; decidua; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiolester hydrolase activity; palmitoyl-CoA hydrolase activity; carboxylic ester hydrolase activity; hydrolase activity; signaling receptor binding; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; protein binding;
Cellular component	mitochondrial matrix; mitochondrion; peroxisomal matrix; cytosol;
Biological process	very long-chain fatty acid metabolic process; long-chain fatty acid metabolic process; acyl-CoA metabolic process; protein targeting to peroxisome; fatty acid metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	10965
	171210
	ENSG00000119673
	ENSMUSG00000021226
	P49753
	Q9QYR9
	NM_006821; NM_001364177; NM_001364178
	NM_134188
	NP_006812; NP_001351106; NP_001351107
	NP_598949
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.^[5]^[6]^[7]

Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze Coenzyme A (CoA) esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA.^[8] ACOT2 shows high acyl-CoA thioesterase activity on medium- and long-chain acyl-CoAs, with an optimal pH of 8.5. It is most active on myristoyl-CoA but also shows high activity on palmitoyl-CoA, stearoyl-CoA, and arachidoyl-CoA.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119673 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021226 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ACOT2 acyl-CoA thioesterase 2".
^ ^a ^b Jones JM, Gould SJ (August 2000). "Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase". Biochemical and Biophysical Research Communications. 275 (1): 233–240. doi:10.1006/bbrc.2000.3285. PMID 10944470.
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (September 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB Journal. 20 (11): 1855–1864. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (September 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". Journal of Lipid Research. 46 (9): 2029–2032. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119673 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021226 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ACOT2 acyl-CoA thioesterase 2".

[pmid10944470-6] Jones JM, Gould SJ (August 2000). "Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase". Biochemical and Biophysical Research Communications. 275 (1): 233–240. doi:10.1006/bbrc.2000.3285. PMID 10944470.

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (September 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB Journal. 20 (11): 1855–1864. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[pmid16103133-8] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (September 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". Journal of Lipid Research. 46 (9): 2029–2032. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

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